Infertility treatment with ICSI microinjection method in Iran

 

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Intra-cytoplasmic injection of microinjection sperm

ICSI microinjection stands for Intra Cytoplasmic Sperm Injection, which translates to intra-cytoplasmic sperm. ICSI, like IUI and IVF, are assisted reproductive techniques (ART). Unlike IUI, in which male sperm enter the uterus through a fallopian tube, in IVF and ICSI, the female's Oocyte combines with the male sperm outside the body and in the laboratory, and after fertilization, the resulting embryo inside. The woman's uterus is implanted.

Read more about Infertility Treatment Using IUI Method in Iran.
 

Differences between infertility treatments, IUI, IVF and microinjection

The difference between IVF and ICSI microinjection is how the Oocyte is fertilized. In IVF, the sperm is exposed to the Oocyte to enter the Oocyte itself, while in ICSI, the sperm is inserted into the Oocyte with a special needle.

 

ICSI microinjection such as IVF and IUI is one of the assisted reproductive techniques (ART). Unlike IUI, in which male sperm enter the fallopian tube through a fallopian tube, in IVF and ICSI, the female's Oocyte combines with the male sperm outside the body, in vitro, and after fertilization, the resulting embryo enters the uterus. The lady is left. The difference between IVF and ICSI is in how the Oocyte is fertilized.

 

In IVF, the sperm is exposed to the Oocyte to enter the Oocyte itself, while in ICSI microinjection, the sperm is inserted into the Oocyte with a special needle. ICSI stands for Intra Cytoplasmic Sperm Injection, which translates to intra-cytoplasmic sperm.

 

When is ICSI microinjection often recommended?

Cases where it is not possible to perform intrauterine insemination (IUI) and in vitro fertilization (IVF) or the results of fertilization in previous IVF cycles have been negative; Using this method can create new hopes in couples for success. This method is usually used in patients whose sperm are of low quality in number and shape.

 

In general, the steps of performing ICSI microinjection operation can be divided into five steps:

Step 1: Stimulate ovulation

Step 2: Collect the Oocyte

Step 3: Prepare the sperm

Step 4: Fertilization and fetal growth in the laboratory

Step 5: Transfer the fetus to the uterus.

Step 6: Pregnancy test.

 

Ovulation stimulation:

By prescribing ovulation-stimulating drugs to a patient's ovaries, large numbers of Oocyte-containing follicles grow. However, with the administration of fertility drugs, a larger number of ovarian follicles grow and reach final maturity, and the ground is prepared for the collection of more Ovum cells. As the number of collected Ovum cells increases, the number of resulting embryos increases and ultimately the chance of fertility increases. Ovulation-stimulating drugs are given to patients in different protocols, which vary according to the patient's Oocyte and condition.

 

These drugs may be used alone or in combination. Ovulation stimulants are often given over a period of 10 to 14 days. Ovulation stimulants are usually started from the first to the third day of the menstrual cycle according to the treatment plan, and from the sixth day, mature follicles are identified using serial ultrasound and daily blood tests.

Finally, HCG is injected to fully mature the Oocyte and release it. Ovulation will occur approximately 36-38 hours after HCG injection. This allows the IVF team to determine the right time to ovulate (puncture).

 

Ovum collection (puncture operation):

The next step after taking ovulation-stimulating drugs is to take an Oocyte or (puncture operation). Ovulation from the vaginal tract by perforating the follicles, their contents, which are Ovum cells and follicular fluid, are inserted into the ovary through a long needle and the mature Ovum cells are collected by a suction pump.

In some cases, the Oocyte is extracted by laparoscopic surgery. Laparoscopy is a surgical procedure that usually requires general anesthesia. In this procedure, the doctor uses a laparoscope to view the ovaries and fallopian tubes, and drains the follicles directly from the ovary using a suction device.

 

Sperm preparation:

On the morning of Oocyte collection, semen is prepared from the patient's spouse, and after washing and preparation, healthy and highly active sperm are removed.

 

Fertilization and fetal growth in vitro:

In the ICSI microinjection method, first the cells around the Oocyte are separated with the help of an enzyme, then the sperm is injected into the Oocyte with a special needle with the help of very advanced microscopes.

A fertilized Oocyte is called an embryo. The unicellular embryo begins to divide and a multicellular embryo develops. If fertilized, the embryos are incubated for another 24 hours to reach the four- to eight-cell stage and ready to be transferred to the mother's uterus. Embryo formation and their number and quality depend on the number and quality of Ovum cells and sperm.

 

Fetal transfer into the uterus:

Embryo transfer is also performed without anesthesia. At this stage, the embryos are placed in a thin tubular device called a catheter and transferred from the vaginal tract to the uterus. The person is usually discharged from medical centers two hours after the transfer of the fetus.

In special cases where it is not possible to transfer the fetus vaginally or at the discretion of the doctor, the transfer of the fetus may be done with the help of laparoscopy, which is called ZIFT.

To increase the chances of pregnancy, more than one fetus is placed in the uterus, which may lead to multiple births. Younger women are more likely to have multiple births. In a woman between the ages of 20 and 29, with three transferred embryos, the chance of having multiple pregnancies is 46 percent.

 

pregnancy test:

After 14 to 17 days of embryo transfer, the amount of HCG in the patient's blood is measured, and an increase in this hormone is the first sign of pregnancy.
 

What you know about Evaluation of genetic defects of PGD embryos in Iran.

Success rate of ICSI microinjection in fertility

All infertility and infertility treatment centers hope that all couples undergoing IVF and ICSI microinjection will have successful and healthy pregnancies. However, the success rate of this method in the most advanced centers of the world is less than 40%. The success rate in the United States for each in vitro fertilization is as follows:

 

30 to 35% for women under 35

25% for women 35 to 37 years old

15 to 20% for women 38 to 40 years old

6 to 10 percent for women over 40

 

Iran has very reasonable costs for infertility treatment and by traveling to Iran for treatment under the supervision of the best infertility specialist and in the best infertility specialized hospitals and you will be treated at the best cost.

 

Cost of ICSI microinjection infertility treatment in the United States: 24,000-32,000 $

The cost of infertility treatment with ICSI microinjection method in Turkey: 3800-4800 $

Cost of ICSI microinjection infertility treatment in the UK: 19,000-28,000 $

Cost of ICSI microinjection infertility treatment in India: 3,000-4,000 $

The cost of infertility treatment with ICSI microinjection method in Iran: 2000-3000 $

Read more about Infertility treatment with IVF in Iran.
 

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